• Julia F Ridpath

Bovine viral diarrhea Group: Group IV Order: Unassigned Family: Genus: Bovine viral diarrhea virus 1 Species Bovine viral diarrhea ( BVD) or bovine viral diarrhoea (UK English), and previously referred to as bovine virus diarrhoea (BVD), is a significant economic disease of that is endemic in the majority of countries throughout the world. The causative agent, bovine viral diarrhea virus (BVDV), is a member of the genus of the family. BVD infection results in a wide variety of clinical signs, due to its effects, as well as having a direct effect on respiratory disease and fertility. In addition, BVD infection of a susceptible dam during a certain period of gestation can result in the production of a persistently infected (PI) fetus.

Learn about the veterinary topic of Diarrhea in Neonatal Ruminants. The viruses of bovine virus diarrhea and. Merck and the Merck Veterinary Manual.

PI animals recognise intra-cellular BVD viral particles as ‘self’ and shed virus in large quantities throughout life; they represent the cornerstone of the success of BVD as a disease. Contents. Virus classification and structure BVDV is a member of the genus, belonging to the family Flaviviridae. Border disease virus (sheep) and virus (pigs) are other members of this genus that also cause significant financial loss to the livestock industry. Pestiviruses are small, spherical, single-stranded, enveloped RNA viruses of 40 to 60 nm in diameter. The genome consists of a single, linear, positive-sense, single-stranded RNA molecule of approximately 12.3 kb. Two BVDV genotypes are recognised, based on the nucleotide sequence of the 5’untranslated (UTR) region; BVDV-1 and BVDV-2.

BVDV-1 isolates have been grouped into 16 subtypes (a –p) and BVDV-2 has currently been grouped into 3 subtypes (a – c). BVDV strains can be further divided into distinct biotypes (cytopathic or non-cytopathic) according to their effects on tissue cell culture; cytopathic (cp) biotypes, formed via mutation of non-cytopathic (ncp) biotypes, induce apoptosis in cultured cells. Ncp viruses can induce persistent infection in cells and have an intact NS2/3 protein. In cp viruses the NS2/3 protein is either cleaved to NS2 and NS3 or there is a duplication of viral RNA containing an additional NS3 region. The majority of BVDV infections in the field are caused by the ncp biotype.

Epidemiology BVD is considered one of the most significant infectious diseases in the livestock industry worldwide due to its high prevalence, persistence and clinical consequences. In Europe the prevalence of antibody positive animals in countries without systematic BVD control is between 60 and 80%. Prevalence has been determined in individual countries and tends to be positively associated with stocking density of cattle. BVDV-1 strains are predominant in most parts of the world, whereas BVDV-2 represents 50% of cases in North America. In Europe, BVDV-2 was first isolated in the UK in 2000 and currently represents up to 11% of BVD cases in Europe. Transmission of BVDV occurs both horizontally and vertically with both persistently and transiently infected animals excreting infectious virus.

Virus is transmitted via direct contact, bodily secretions and contaminated fomites, with the virus being able to persist in the environment for more than two weeks. Persistently infected animals are the most important source of the virus, continuously excreting a viral load one thousand times that shed by acutely infected animals. Pathogenesis. ^ Fray; et al.

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Julia F Ridpath

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